Trafficking from the biosynthetic pathway: more coats and adaptors In animal cells, the major pathway for diverting lysosomal enzymes from the flow of proteins to the cell surface involves sorting at the TGN via mannose 6-phosphate receptors

The endosomal system is a major membrane-sorting apparatus. New evidence reveals that novel coat proteins assist specific sorting steps and docking factors ensure the vectorial nature of trafficking in the endosomal compartment. There is also good evidence for ubiquitin regulating passage of certain proteins into multivesicular late endosomes, which mature by accumulating invaginated membrane. Lipids play a central role in this involution process, as do the class E vacuolar protein-sorting proteins.